Med. , 160 , 612 C 617 ( 1984. that ATL\43T cells infiltrated in to the lymphoid organs preferentially, like the thymus and spleen, and proliferated there. Hence, the radiometric methods used in this research were very helpful to judge the proliferation sites of ATL\43T cells in SCID mice. Furthermore, this murine model could provide Polydatin us a chance to check the feasibility of healing program of radiolabeled anti\Tac MoAb. cell proliferation of adult T\cell leukemia . Bloodstream , 82 , 2501 C 2509 ( 1993. ). [PubMed] [Google Scholar] 8) Hattori , T. , Asou , N. , Suzushima , H. , Takatsuki , K. , Tanaka , K. , Naito , K. , Natori , H. and Oizumi , K.Leukaemia of book gastrointestinal T\lymphocyte inhabitants infected with HTLV\We . Lancet , 337 , 76 C 77 ( 1991. ). [PubMed] [Google Scholar] 9) Bosma , Polydatin G. C. , Custer , R. P. and Bosma , M. J.A serious combined immunodeficiency mutation in the mouse . Character , 30 , 527 C 530 ( 1983. ). [PubMed] [Google Scholar] 10) Uchiyama , T. , Broder , S. and Waldmann , T. A.A monoclonal antibody (anti\Tac) reactive with activated and functionally mature individual T cells. I. Creation of anti\Tac monoclonal antibody and distribution of Tac(+) cells . J. Immunol. , 126 , 1393 C 1397 ( 1981. ). [PubMed] [Google Scholar] 11) Uchiyama , T. , Nelson , D. L. , Fleisher Polydatin , T. A. and Waldmann , T. A.A monoclonal antibody (anti\Tac) reactive with activated and functionally mature individual T cells. II. Appearance of Tac antigen on turned on cytotoxic T cells, suppressor cells, and using one of two types of helper T cells . J. Immunol. , 126 , 1398 C 1403 ( 1981. ). [PubMed] [Google Scholar] 12) Tsudo , M. , Uchiyama , T. and Uchino , H.Appearance of Tac antigen on activated regular individual B cells . J. Exp. Med. , 160 , Polydatin 612 C 617 ( 1984. ). [PMC free of charge content] [PubMed] [Google Scholar] 13) Uchiyama , T. , Hori , T. , Tsudo , M. , Wano , Y. , Umadome , H. , Tamori , S. , Yodoi , J. , Maeda , M. , Sawami , H. and Uchino , H.Interleukin\2 receptor (Tac antigen) portrayed on adult T cell leukemia cells . J. Clin. Invest. , 76 , 446 C 453 ( 1985. ). [PMC free of charge content] [PubMed] [Google Scholar] 14) Tsudo , M. , Uchiyama , T. , Uchino , H. and Yodoi , J.Failing of legislation of Tac antigen/TCGF receptor on adult T cell leukemia cells by anti\Tac monoclonal antibody . Bloodstream , 61 , 1014 C 1016 ( 1983. ). [PubMed] [Google Scholar] 15) Hunter , W. N. and Greenwood , F. C.Planning of iodine\131 labeled hgh of high particular activity . Character , 194 , 495 C 496 HDAC11 ( 1962. ). [PubMed] [Google Scholar] 16) Hnatowich , D. J. , Childs , R. L. , Lanteigne , D. and Najafi , A.The preparation of DTPA\coupled antibodies radiolabeled with metallic radionuclides: a better method . J. Immunol. Strategies , 65 , 147 C 157 ( 1983. ). [PubMed] [Google Scholar] 17) Saga , T. , Endo , K. , Akiyama , T. , Sakahara , H. , Koizumi , M. , Watanabe , Y. , Nakai , T. , Hosono , M. , Yamamoto , T. , Toyoshima , K. and Konishi , J.Scintigraphic detection of overexpressed c\protooncogene products with a class\switched murine anti\c\protein monoclonal antibody.