Supplementary MaterialsAdditional file 1: Furniture S1, S2, S11, S12, S13, and S14. by the number of pups subjected to genotyping (GM pups/pups genotyped). Table S12. ABT-046 Sanger sequencing of detailed genotype of mutant DNA sequences in all the five mouse lines. Table S13. Primers and PCR conditions utilized for genotyping the mutant alleles of the […]
Category: Ca2+Sensitive Protease Modulators
Supplementary MaterialsSupplementary information 41598_2019_43627_MOESM1_ESM
Supplementary MaterialsSupplementary information 41598_2019_43627_MOESM1_ESM. although several immunomodulatory regimens have conferred beneficial effects in improving symptoms and/or survival when used for treating HD mice35,36. Our results further suggest that the immune system, specifically TNF, may contribute to Sav1 HD progression, and that targeting this cytokine may slow down the brain deterioration found associated with disease. Further […]