Background: A lot more than 700 plants are reported to be used for medicinal purposes in Nepal; however, many of them are not studied for their scientific evidences. various secondary metabolites, including alkaloids, flavonoids, reducing sugars, saponins, terpenoids and tannins. The amounts of total phenolics and flavonoids were found to be the highest in leaf extract, which showed the most potent free of charge radical scavenging activity also. Draw out of fruits demonstrated the best -amylase inhibitory activity, whereas the components of leaves and leaves exhibited moderate activity. Conclusions: A number of the therapeutic vegetation selected with this research demonstrated high TPC and TFC ideals and powerful bioactivities. These total results might provide the medical evidences of the original uses of the plants. However, further complete research on bioactive substances isolation and recognition and evaluation of in vivo pharmacological actions ought to be performed in long term. Wall structure. (Gesneriaceae), Lour. (Loganiaceae), L. (Caricaceae), (Nees) Keng f. (Gramineae) and (L. f.) Kurz (Anacardiaceae), from Traditional western Nepal and screened for his or her phytochemical constituents and natural activities. can be an epiphytic sub-shrub distributed in Tenovin-3 India, Nepal, Sikkim, Bhutan, Southern China, Burma, Vietnam and Thailand [6]. Main decoction can be used for the treating fever, as well as the infusion of leaves can be used to take care of tonsillitis in Mizoram, India [7]. Vegetable juice, about 4 teaspoons each day double, really helps to conceive. Powdered leaf, mixed with rice flour, is baked and taken Tenovin-3 for backaches [4]. is a tropical tree, native to central America and now widely cultivated in all tropical and sub-tropical regions for its edible fruits and its latex [10]. The medicinal properties of are well documented in traditional systems of medicine [11] Latex of papaya is anthelmintic and used for wound healing and skin diseases. Leaf decoction is used for asthma and rheumatism. The unripe fruits are used as a laxative and diuretic [12,13]. is a deciduous tree, 10C15 m tall, Tenovin-3 indigenous to Southeast Asian countries [16,17]. Different parts of (leaves, bark, fruits, and roots) have been used for the treatment of various disorders. For example, the fresh leaves of are used to treat gastrointestinal disorders, and the ripe fruits are consumed raw or as juice as a liver tonic and appetizer in Nagaland, India [18]. The bark is used for the treatment of dysentery, muscular rheumatism and diabetes mellitus [19]. The fruits are eaten fresh or pickled. Bark decoction is given for dysentery, gonorrhea and rheumatism [20]. The roots are used for regulating menstruation [21]. The main aims of the present study were the estimation of the total phenolic and flavonoid contents, and the evaluation of the free radical scavenging and leaves (127.48 1.58 mg GAE/g, and 648.42 2.88 mg QE/g, respectively), followed by leaves (71.50 1.39 mg GAE/g, and 425.08 1.44 mg QE/g, respectively). The shoots extract showed the lowest phenolic and flavonoid contents (Table 3). Table 3 The TPC and TFC values a of the five extracts. leaf extract exhibited the strongest free radical scavenging activity with an IC50 value of 3.04 0.04 Tenovin-3 g/mL, followed by the leaf extract (IC50 = 4.84 0.12 g/mL), when compared to the positive control, ascorbic acid (IC50 = 3.16 0.03 g/mL). Table 4 The IC50 values a for the DPPH free radical scavenging and -amylase inhibitory activities of the extracts. fruit extract showed the most potent activity with an IC50 value of 0.45 0.02 mg/mL. Similarly, the leaves (IC50 = 1.59 0.01 mg/mL) and leaves (IC50 = 2.11 0.01 mg/mL) exhibited a moderate inhibitory activity against the -amylase enzyme. 4. Discussion Plants contain diverse bioactive compounds, also known as secondary metabolites, which are reported to Rabbit Polyclonal to Notch 2 (Cleaved-Asp1733) exhibit various health promoting activities in the human body, including antioxidant activity [28,29]. One such chemical class.