Introduction MERS is the effect of a viral disease, which was initial identified in KSA, 2012. individuals infected by MERS-CoV during Winter season and Fall months time of year were 4.09 times greater than those patients who infected during Springtime and Summer months (OR = 4.09, CI 1.18-14.15, P 0.026). Weighed against MERS-CoV individuals who got Non-Chronic kidney illnesses, the chances of loss of life the MERS-CoV individuals who got chronic kidney illnesses had been 18.08 times higher (OR = 18.08, CI -2.01-162.99, P 0.01). Summary The entire case fatality price of MERS-CoV disease was high. Further research with large test sizes are had a need to explore the reason why behind the reduction in the mortality price over the period of time. strong course=”kwd-title” Abbreviations: MERS-CoV, Middle CD209 East Respiratory Symptoms coronavirus; KSA, Kingdom of Saudi Arabia; RT PCR, Real-time polymerase string response; CKD, Chronic Kidney Disease solid course=”kwd-title” Keywords: Demographic, Clinical, Result, MERS-CoV, Najran History Bekanamycin Middle East Respiratory Symptoms (MERS) is caused by a viral infection, the virus belongs to a large family of viruses called genus Beta coronavirus (CoV) . Middle East Respiratory Syndrome coronavirus (MERS-COV) is a zoonotic illness, infecting both humans and animals (camels and bats). Only two strains of coronaviruses were found to infect humans: MERS-CoV and Severe Acute Respiratory Syndrome whereas different species of animals are infected by several strains of corona viruses . The MERS-CoV causes upper respiratory disease in human being, which ranges from mild to moderate . In September 2012, the MERS-CoV was identified in Jeddah, Kingdom of Saudi Arabia (KSA) as Bekanamycin a first public case . The first nosocomial outbreak of MERS-CoV was reported in Al Zarqa, Jordan (eight healthcare workers) . Subsequently, 2189 cases (782 deaths) of MERS-COV around the world were reported to World Health Organization from September 2012 to March 2018. Of 2189 cases worldwide, KSA reported 1814 cases (708 deaths) to WHO. Approximately 27 countries around the world have reported cases of MERS-CoV. Such countries included KSA, Qatar, Oman, Kuwait, Jordan, United Arab Emirates, Yemen, Bahrain, Lebanon, Egypt, Turkey, United Kingdom, United States, France, Germany, Austria, Algeria, Greece, Islamic Republic of Iran, China, Republic of Korea, Tunisia, Thailand, Malaysia, Italy, the Netherlands, and Philippines . According to published studies, Arabian Peninsula has represented the geographic distribution of the MERS-CoV cases mainly, nevertheless, KSA was reported the best percentage of instances [, , , ]. In a few nationwide countries that situated in Asia, Africa, European countries, and THE UNITED STATES, they reported how the MERS-COV was recognized in people via endemic countries [, , , , , , ]. Research show a indirect and direct connection with infected camels potential clients to human Bekanamycin being disease. Indirect contact contains ingesting camel’s unpasteurized dairy and non-well prepared meat [, , ]. The primary reservoir from the MERS-CoV may be the dromedary camels which infect human beings. However, the mode of transmission from camels to human being isn’t known completely. In term of transmitting from human beings to human beings, the disease will not transmit between human beings unless of course there is certainly close get in touch with basically, for example, coming in contact with the individual hands. It could be sent among people by contact with contaminated individuals respiratory secretion such as for example sneezing and coughing [6,20,21]. The symptoms of MERS-CoV involve shortness of breathing, cough, and fever. Furthermore, diarrhea and additional gastrointestinal system symptoms have already been reported by many individuals [6,, ]. Real-time polymerase string response (RT PCR) is available to be the best available confirmatory test of the MERS-CoV. It’s also accurate for assessment of respiratory swabs and serum [24,25]. Regarding the treatment, it relies on a clinical situation of the patient and is considered supportive. Therefore, there is no current specific medication or vaccine . There are preventive recommendations by Centers for Disease Control and Prevention (CDC) to prevent spreading of MERS-CoV among humans in communities, homes, and healthcare facilities. In term of communities and homes, the guidelines for people confirmed with the infection of the MERS-CoV; A) They should stay at home without going school, public places, or work, B) They have to be separated from other house members in a different room, C) They have to wear a facemask, D) They should inform healthcare providers when there is a medical appointment, E) They should cover their nose and mouth by tissue.